The disease itself forms via atherosclerosis, a condition defined by a build-up of plaque (or fatty deposits) within the arteries. This plaque build-up causes the arteries supplying the limbs (known as the peripheral arteries) to narrow and harden, thereby restricting blood flow to the limbs, .
Half of people with PAD do not experience any symptoms, however those that do may have symptoms including, :
The current standard of treatment includes lifestyle changes, prescription medication, and sometimes surgery.
For cholesterol control
For high blood pressure
For diabetes control
Insulin / antiglycaemic drugs
For blood clot prevention
acute limb ischaemia; or critical limb ischaemia, when in the chronic (longer term) and not acute stage
Acute decrease in blood flow to the limb due to plaque in the peripheral arteries breaking off and causing a blockage.
If blood flow to the limbs is heavily restricted, this can result in tissue death or amputation.
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